Endocrine Abstracts

IntroductionExercise induces changes in the inflammatory profile that can comprehend changes during and immediately after exercise with long-term effects. This inflammatory profile could impact the cognitive function and so, the performance.ObjectivesCompare the inflammatory status from long duration and endurance exercises and correlate it with an immune and neuroendocrine genetic profile.<p class="abste...

Background: Several studies have highlighted the contribution of adipose tissue dysfunction to the development and progression of Alzheimer’s Disease (AD), which may depend on alterations in adipokine secretion. Leptin and adiponectin are the most abundant adipokines in circulation, with recognized systemic effects, but also able to cross the blood-brain barrier and influence cognitive-related structures, such as the hippocampus.Objective: To determ...

Serum total cortisol has been linked to increased mortality in patients with Covid-19, but its reliability in critically ill patients is limited. We examined the association between serum free cortisol (SFC) levels and clinical outcomes in patients hospitalized with Covid-19 between 5/5/2020 and 1/3/2021 in our institution. Methods: SFC was measured in blood samples collected at patient’s admission, prior to any medical treatment. Patients’ fil...

Introduction: Acute Kidney Injury (AKI) is highly prevalent during hospitalization of patients with type 2 diabetes (T2D), and has been associated with increased risk of hypoglycaemia in Intensive Care Units. However, this association in non-critically ill patients is less clear and evidence on the impact of AKI’s severity and duration on hypoglycaemia is lacking.Objectives: To assess the impact of AKI and its severity and duration on the risk of hy...

Introduction: Myxedema coma is the ultimate stage of severe long-standing hypothyroidism, representing a true endocrinological emergency. Many precipitating factors have been identified, including the initiation of certain drugs.Case report: An 89-year-old woman was admitted to our emergency department due to an inaugural seizure. There was a history of progressive functional deterioration in the last 7 weeks, short after being diagnosed with lymph node ...

Introduction: Autoimmune Thyroid Diseases (AITD) are one of the most prevalent autoimmune diseases in industrialized countries (5% of population). The two main phenotypes of AITD, Hashimoto thyroiditis (HT) and Graves’ disease (GD), are both characterized by the presence of circulating thyroid antibodies and infiltration by autoreactive lymphocytes in the thyroid gland and sometimes the orbit. One of the most studied mechanisms underlying AITD is the imbalance between imm...

Introduction: Hypothyroidism caused by autoimmune thyroiditis (AIT) is a disease that can originate physical, psychological and behavioral symptoms. Quality of life (QoL) and psychopathologial symptoms in thyroid diseases and its relation with thyroid function remains unclear. In hypothyroidism there is a discussion about the normal range of TSH and Free T4 values and in which way its fluctuation influences the patient in its daily activities.Objective: ...

Introduction: Sheehan Syndrome (SS) is a cause of hypopituitarism resulting from postpartum pituitary infarction. Its frequency is decreasing worldwide, particularly in developed countries due to advances in obstetric care. Case report: A 50-year-old female patient was admitted to the emergency department with complains of progressive pain in the lower hemithorax and abdomen. She also referred constipation, weight gain and asthenia. The initial laborator...

Introduction: Hypopituitarism is a rare entity that can have different aetiologies. Symptoms are usually progressive and non-specific; therefore, many patients are underdiagnosed and untreated. We present a clinical case of a patient presenting septic shock, hyponatremia and central hypothyroidism.Case report: A 46-year-old man was admitted in ICU for septic shock of unknown origin and multiorgan failure. Hormonal profile showed central hypothyroidism, p...

Introduction: The prevalence of Transgender individuals seeking gender affirming hormone therapy (GAHT) has been increasing. It is important to closely monitor this therapy in order to minimize the risk of adverse effects.Aim: To evaluate the safety and monitoring of the GAHT in the Portuguese adult transgender populationMethods: Cross-sectional study conducted in March 2021. Data collected through an online questionnaire ...